MAPT and Alzheimer disease: The stabilization energies of Sc37, S17R4C, S17R37N/C fibrils were also comparable to the values reported for reversible amyloids such as FUS (−14.4 kcal/mol/layer29; −14.0 kcal/mol/layer22; −12.2 kcal/mol/layer28) and hnRNPA2 (−21.4 kcal/mol/layer30), but much smaller than those of the pathological fibrils from Alzheimer’s disease-associated tau (−68.9 kcal/mol/layer31) and multiple system atrophy-associated α-synuclein (Type I: −80.4 kcal/mol/layer; Type II: −73.0 kcal/mol/layer32).