Compared to vehicle-treated controls, menopausal AD mice showed no significant differences in plasma levels of IL-10 (p = 0.0632), IFN-γ (p = 0.1482), IL-2 (p = 0.1276), or IL-1β (p = 0.9791) (Fig. 4E–H). This evidence concerns the gene IL1B and Alzheimer disease.