CD274 and Sepsis: Here we leverage the construction of Cre-lox mouse models to produce mice constitutively lacking either PD-L1 gene expression on endothelial cells (ecPD-L1−/−) or neutrophils (pmnPD-L1−/−), respectively, to test the hypothesis that endothelial cell as opposed to neutrophil deficiency PD-L1 differentially contributes to shock/ sepsis induced lung injury/ death.