CD274 and Sepsis: However, whether this is a result of autocrine/ paracrine actions of PD-L1 expression among neutrophils leading to the suppression of the neutrophil’s typically inflammatory activities commonly seen/detected in response to the stimuli associated with shock/sepsis or is it a result of neutrophil expressed PD-L1 ligating a target on the vascular endothelial cell, possibly PD-1 (which an EC can express under inflammatory stressors, etc. [59]) remains to be established here.