CD274 and acute respiratory distress syndrome: In this regard it is worth noting that while less cell-lineage selective in nature, Xu et al [31] use of liposomally encapsulated PD-L1 siRNA intra-venous delivery at 2 hours post-Hem/CLP to mitigate morbid effects of this dual insult indirect ARDS model supports the PD-L1 as a potential early (2–24 hours post-insult) temporal target.