In contrast, mice with specific Dhps deletion in intestinal epithelial cells exhibited spontaneous colitis and inflammation of the small intestine, increased susceptibility to dextran sulfate sodium-induced and C. rodentium-mediated colitis, and exacerbated tumorigenesis in response to the carcinogen azoxymethane (Gobert et al. 2024; Gobert et al. 2023) compared to Dhpsfl/fl animals. Here, DHPS is linked to colitis.