To examine the association between AD biomarkers and cognitive performance, we conducted partial Pearson correlations between the PACC cognitive composite score and three imaging-based summary metrics representing cortical thickness or signature, amyloid burden as measured with the Centiloid scale, and tau burden or Tauopathy, controlling for age, years of education, sex, and APOE ε4 carrier status (details of each metric can be found in the Online Methods). The gene discussed is APOE; the disease is Alzheimer disease.