Additionally, integrative analysis of cirrhosis, a more advanced stage of MASLD, revealed the strongest positive correlations with TFs like CEBPA, HNF4A, and NR2F6, and negative correlations with TFs such as GABPA (Fig. 1Qand Extended Data Fig. 4H-4I), which is involved in oxidative phosphorylation23. This evidence concerns the gene HNF4A and metabolic dysfunction-associated steatotic liver disease.