NR4A1 and neurodegenerative disease: Sex differences in cognitive function are, clinically, most commonly observed in AD, a neurodegenerative disease wherein 2/3 of patients diagnosed with AD are female.[2] The prevailing theory is that this disparity is because of a loss of estrogen, as it is a neuroprotective factor that decreases with age and has been linked to neurodegenerative diseases in post-menopausal women.[50] Interestingly, we did not identify any hormone receptors to be differentially expressed in our transcriptomic data.