Our findings with sensorimotor gating deficits in female Dek cKO, as indexed by prepulse inhibition (PPI), underscore the involvement of a distributed neural network that includes the hippocampus, medial prefrontal cortex (mPFC), and other regions including the striatum.[55, 56] Impairments within this circuitry have been consistently associated with cognitive inflexibility, attentional dysfunction, and executive deficits in neuropsychiatric and neurodegenerative conditions, including schizophrenia and Alzheimer’s disease. This evidence concerns the gene DEK and Alzheimer disease.