DEK and early-onset autosomal dominant Alzheimer disease: Our findings with sensorimotor gating deficits in female Dek cKO, as indexed by prepulse inhibition (PPI), underscore the involvement of a distributed neural network that includes the hippocampus, medial prefrontal cortex (mPFC), and other regions including the striatum.[55, 56] Impairments within this circuitry have been consistently associated with cognitive inflexibility, attentional dysfunction, and executive deficits in neuropsychiatric and neurodegenerative conditions, including schizophrenia and Alzheimer’s disease.