Multiple System Atrophy (MSA) is a rare, sporadic, age-related synucleinopathy characterized by accumulation of a-synuclein (aSyn) in the form of glial cytoplasmic inclusions (GCI) in the oligodendrocytes of the central nervous system, leading to myelin loss, neuronal loss and neuronal inflammation. This evidence concerns the gene SNCA and multiple system atrophy.