RBFOX3 and multiple system atrophy, cerebellar type: In contrast, biotinylated ASO co-localized with both neurons (NeuN) and astrocytes (GFAP) in the corpus callosum, cerebellum and brainstem in both MBP-aSyn tg and non-tg mice (Supplemental Figure 3A–F) Thus, although systemic delivery of aSyn ASO with the ApoB11 peptide did cross the BBB and enter the CNS, it did not reach the target cell (oligodendrocyte) in the MBP-aSyn tg mouse model of MSA-C.