AKT1 and Alzheimer disease: In addition, most of the pEVs proteins significantly correlated with main AD features (CSF Aβ42 and pTau, Qalb and MMSE) were involved in Akt signaling pathways (widely described to be one of the main molecular routes in AD), as well as, inducible expression of cytokine genes in T-cells, NF-kappa-B activation, intracellular trafficking, and multivesicular bodies formation (the initial step of EV biogenesis).