Similarly, proteins such as MMP8, IL32, NDRG1, SMOC2, or ESM1, which have been previously reported to contribute to AD pathology [53–57], showed to be significantly increased in both MCI A + T + and AD dementia, but not in MCI A-T-, suggesting a specific AD-related signature in pEVs proteome. The gene discussed is SMOC2; the disease is Alzheimer disease.