Regarding specific proteins, such MICB_MICA, known to activate natural killer cells, or AOC1, which regulates many biological processes including inflammation, appeared highly correlated with increased volumes of different brain regions typically affected in AD (i.e. hippocampus and cortex) as well as other areas, such as the caudoputamen, thalamus or the amygdala. Here, AOC1 is linked to Alzheimer disease.