The enrichment of pathways related to AD, PD, HD, and prion disease, Figure-2 (i) through (l), across all cell types is a critical finding, along with the downregulation of MYC targets V1 and V287,88 in both excitatory and inhibitory neurons, alongside dysregulated heavy metal absorption pathways (e.g., zinc and selenium) in inhibitory neurons is also seen AD87–89. The gene discussed is MYC; the disease is prion disease.