Relatively, intermediate and advanced AD had enrichment of these gene-sets in fewer cell-types, with DNA repair gene-sets finding significance only if excitatory and inhibitory neurons are considered together and UV gene sets find significance in some individual cell-types, like Sncg, L4 IT and L5 IT in intermediate AD, and Pax6, L5 IT and L6 IT in advanced AD. The gene discussed is SNCG; the disease is Alzheimer disease.