We did not observe significant alterations in ASCT2 expression (protein) in DU-145 cells when cultured in hypoxic conditions in vitro, but the same conditions decreased ASCT2 expression in LNCaP cells (Fig. S2) and increased ASCT2 expression (mRNA, protein) in pancreatic cancer cell lines61. Here, SLC1A5 is linked to familial pancreatic carcinoma.