In tumor-specific stem-like (tSTM, cluster 0) cells, hallmark programs, including TNFα/NFκB signaling, epithelial–mesenchymal transition (EMT), KRAS signaling, E2F targets, and G2/M checkpoint, were significantly upregulated, consistent with a proliferative, inflammatory, and invasive transcriptional state. This evidence concerns the gene TNF and neoplasm.