CTLA4 and melanoma: Four species were associated with the non-reactive cluster: the Lachnospiraceae SGB4573, the Clostridia SGB14306, Massilimaliae massiliensis (already described in patients with melanoma and/or NSCLC exhibiting progressive disease despite PD-1 and/or cytotoxic T-lymphocyte associated protein 4 (CTLA-4) blockade21), and the Eggerthellaceae SGB63101 (log-gamma average (avg).