PKP2 and arrhythmogenic right ventricular cardiomyopathy: Approximately 60% of ARVC cases are due to mutations in desmosomal genes, with plakophilin-2 (PKP2) being the most prevalent; about 30% are considered gene-elusive (GE), with the causative genetic variants remaining unidentified8, 9, 10, 11, 12.