Several studies have reported that TBK1 negatively regulates mTORC1 activity through phosphorylation of Raptor at Ser877, particularly under chronic innate immune activation, such as in Trex1-deficient or prostate cancer models, where TBK1 suppresses mTOR-driven anabolic programs and promotes cellular quiescence or dormancy28. Here, RPTOR is linked to prostate carcinoma.