CAR19-IL18 T cells, engineered to secrete interleukin-18 (IL-18), are designed to enhance activation, proliferation, and tumor infiltration, while CAR19-GOT2 T cells, engineered to overexpress GOT2 (a metabolic enzyme) to enhance metabolic fitness and exhaustion resistance, displayed a distinctive mechano-metabolic signature. The gene discussed is IL18; the disease is neoplasm.