CASP3 and adrenal cortex carcinoma: In contrast, there was no significant increase in cleaved caspase 3 and cleaved PARP when ACC cells were treated with STA9090, BGT226, or the combination of these two drugs, suggesting that the cell death caused by BGT226 and STA9090 was not caspase or PARP-dependent apoptosis (Supplementary Fig. 12).