We found that patients with ACC and high expression of HSP90B1 (OS: P =0.007, DFS: P <0.001), HSP90B3P (OS: P =0.092, DFS: P =0.084), PIK3R1 (OS: P <0.010, DFS: P =0.092), AKT2 (OS: P=0.002, DFS: P <0.001), HSP90AB2P (DFS: P=0.019) and HSP90B2P (DFS: P=0.044), were associated with either shorter OS or shorter DFS or both (Fig. 1c, Supplementary Fig. 3, 4). This evidence concerns the gene AKT2 and adrenal cortex carcinoma.