Specifically, higher PPARG was associated with higher PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2) expression which in turn was associated with lower Clinical Dementia Rating (CDR) in T2DM (i.e., +PPARG ◊ +PRKAG2 ◊ −CDR). Here, PRKAG2 is linked to type 2 diabetes mellitus.