PRDM15 and holoprosencephaly: While no changes in hematopoiesis were explored or reported in human with biallelic PRDM15 loss-of-function variants, families with such mutations have been identified with Galloway-Mowat syndrome (GAMOS) or holoprosencephaly (HPE), demonstrating that loss of PRDM15 disrupts normal renal and brain development23,36.