MOXD1 has been implicated in the progression of AMD37 and anemia.38MOXD1 is also known to affect tau protein levels, which may lead to modifications in neuronal injury associated with ocular hypertension.39,40 Lastly we identified a POAG-associated intronic variant on chromosome 9 which encodes UBAP2, a gene associated with the neurodegenerative disease amyotrophic lateral sclerosis41, in which astrocytes play a role in both ALS disease and in changes to the optic nerve head in glaucoma.42 The gene discussed is MOXD1; the disease is open-angle glaucoma.