TMCO1 and open-angle glaucoma: On chromosome 1, we observed a significant number of associated variants near the TMCO1 gene, which has been implicated in various disorders, including POAG, craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome.22TMCO1 plays a crucial role in regulating intraocular pressure (IOP), a key factor in the development of POAG.