One such locus is centered at 52.5 Mb on chromosome 1 near the TUT4 gene, which is responsible for uridylating miRNAs.27 This gene is related to glutathione peroxidase 7, where changes in enzyme activity may contribute to age-related macular degeneration (AMD).28,29 Furthermore, TUT4 has been linked to height,30 with studies suggesting that individuals who are taller or have lower body mass index tend to have a smaller neuroretina rim area and a larger optic cup-to-disc area ratio.31 Here, TUT4 is linked to age-related macular degeneration.