Dysregulation of TMCO1 may hinder the outflow of aqueous humor potentially resulting in elevated IOP levels.23,24 Additionally, on chromosome 1, we replicated the association near the pseudogene LOC440700 and the TMCO-AS1 gene which have both been previously reported in POAG GWAS.25,26. This evidence concerns the gene TMCO1 and open-angle glaucoma.