Among the sixty-seven proteins down-regulated in the SCA-HU group compared to the untreated SCA, we found a decrease in Interferon Related Protein’s expression such as OAS3, ISG15, MX1, IFIT3, IFIT1, GBP1, MX2, STAT1 and IFI35 (Figure 7A). This evidence concerns the gene MX2 and autosomal dominant cerebellar ataxia.