Among the sixty-seven proteins down-regulated in the SCA-HU group compared to the untreated SCA, we found a decrease in Interferon Related Protein’s expression such as OAS3, ISG15, MX1, IFIT3, IFIT1, GBP1, MX2, STAT1 and IFI35 (Figure 7A). The gene discussed is ISG15; the disease is autosomal dominant cerebellar ataxia.