Notably, NeutroP from patients with SCA showed increased expression of Interferon Related Genes (ISG15, IFI44L, MX1, IRF9) and genes associated with Inflammatory response (SELL and C1QTNF4) in SCA NeutroP (Figure 3E, Table S3). Here, C1QTNF4 is linked to autosomal dominant cerebellar ataxia.