2D annotation enrichment test using Reactom annotation databases shows expression pattern enriched with IFN signaling, particularly type I-IFN pathways within a down-regulation of Interferon-related proteins expression in SCA-HU neutrophils compared to untreated SCA neutrophils (Figure 7B), confirmed by DEG analysis (Figure 7C). Here, IFRD2 is linked to autosomal dominant cerebellar ataxia.