Taken all the data together, Our study identified an important master switch, the CEBPB-LAP isoform, which drives Mon-gene-signature, that connects the cellular phenotypes (lipid accumulation, and mitochondria accumulation by defective autophagy) of obesity to neurodegenerative diseases, non-alcoholic fatty liver disease, and diabetic cardiomyopathy. The gene discussed is CEBPB; the disease is metabolic dysfunction-associated steatotic liver disease.