Using human hepatocellular carcinoma (HCC) patient data, and HBV-positive HCC cell line experimentation here we show that, CEBPB-LAP overexpression is tightly linked to Mitochondriaobesity/neurodegeneration (Mon) mRNA expression signature and the core enriched Mon genes have CEBPB ChIP-seq binding properties at transcription start sites (TSS). Here, CEBPB is linked to hepatocellular carcinoma.