As the Mon-gene-signature primarily involves chloroquine sensitive ETC, we continued to experiment its effect on HBV, PSENEN (γ-Secretase gene), DEPTOR (another obesity regulator), ADAR1, an A-to-I RNA-editing enzyme that regulate HBV replication45, and DEPTOR mRNA46 a γ-Secretase/Notch1/NICD target. The gene discussed is ADAR; the disease is obesity due to melanocortin 4 receptor deficiency.