In particular, for both p-tau217 and NfL, we observed significant difference across cognitive status (F(2, 954) = 12.61, p < 0.001, partial η2 = 0.03 for p-tau217, F (2, 953) = 35.40, p < .001, partial η2 = 0.07 for NfL), with the difference between CU and dementia remaining significant after Tukey correction for both biomarkers (p < 0.05). This evidence concerns the gene NEFL and dementia.