Besides LOAD, APOE polymorphism also affects the risk of occurrence and the rate of progression of several other neurodegenerative diseases including primary tauopathies, α-synucleinopathies, and age-related macular degeneration, but unlike LOAD, in some of these entities not the ε4 allele but the ε2 allele has been found to produce worse outcomes [46, 58, 128]. This evidence concerns the gene APOE and synucleinopathy.