After adjusting for age, observation time, nadir CD4 + cell count, C3 AIDS stage, HCV coinfection, and number of cardiovascular risk factors, the only factor associated with CVEs was combination of HS-IR and risk of fibrosis (HR, 2.21; 95% CI, 1.2–4.1; p < 0.01), whereas HS-IR or risk of fibrosis was not (HR, 1.3; 95% CI, 0.75–2.27; p = 0.34) (Table 2). Here, CD4 is linked to fibrosis.