SIMI manifests as myocardial depression, arrhythmias, and elevations in cardiac biomarkers such as B-type natriuretic peptide (BNP), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI), which correlate with poor prognosis (6–8). The gene discussed is TNNI3; the disease is Arrhythmia.