Moreover, in a methionine and choline deficient (MCD) diet-induced mouse model of non-alcoholic steatohepatitis (NASH), activation of SIRT1 inhibited NF-κB signaling pathway and exerted anti-steatotic, anti-inflammatory, and anti-apoptotic effects105. This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatohepatitis.