In a HFD-induced mouse model of MASLD, activation of the SIRT1/Nrf2 signaling pathway was shown to restore the activity of antioxidant enzymes (e.g., SOD), reduce liver ROS production, and subsequently improve lipid metabolic dysregulation and liver injury associated with MASLD45. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatotic liver disease.