In 2024, Jiang et al. indicated that Saikogenin A (SGA), a metabolite of Saikosaponin A (SSa) from Radix Bupleuri, improves alcohol-induced liver injury by targeting SIRT1 to modulate lipid metabolism in both the National Institute on Alcohol Abuse and Alcoholism (NIAAA)-based mouse model and HepG2 cells (human HCC cells) model of ALD79. Here, SIRT1 is linked to hepatocellular carcinoma.