SIRT1 and metabolic dysfunction-associated steatotic liver disease: Furthermore, Tian et al. demonstrated that the Xie Zhuo Tiao Zhi (XZTZ) formula alleviated MASLD by modulating SIRT1, which suppressed NLRP3 inflammasome-mediated pyroptosis in macrophages, reduced M1 polarization while promoting M2 polarization, and concurrently improved mitochondrial function and lipid metabolism52.