Elurbide J et al.69 reported that arginine methyltransferase 5 (PRMT5) and methylated epitope protein 50 (MEP50) were highly expressed in CCA, which was closely related to the methylation of Arg, and that targeting PRMT5 had significant antitumor efficacy in clinically relevant CCA models. The gene discussed is WDR77; the disease is cholangiocarcinoma.