M1-like TAMs are known for their ability to promote inflammation through the release of many proinflammatory factors, such as inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), interleukin-12 (IL-12) and IL-23, which promote the T helper 1 (Th1) cell immune response and have strong proinflammatory and tumor suppressive abilities. Here, NOS2 is linked to neoplasm.