IFNG and neoplasm: Mechanistically, intact IFN-γ signaling amplifies a suite of tumor programs that cooperate with CAR-T activity—enhanced antigen processing/presentation, upregulation of adhesion and death-receptor pathways (e.g., ICAM-1, FAS), and chemokine remodeling—whereas pathway loss diminishes immunologic visibility and T-cell engagement, blunting cytotoxicity 85.