E2F1 and breast carcinoma: To further validate the clinical relevance of the strong correlation between FTO and BTK in breast cancer, and to investigate the potential impact of FTO-BTK modulation on c-Myc and E2F1 expressions, we utilized the GEPIA 2.0 database for correlation analysis between FTO/BTK expression levels and the expression of c-Myc and E2F1, revealing significant positive correlations (Fig. 9C-G).