Given that USP5 is a deubiquitinase that can inhibit protein degradation by deubiquitination and that USP28, a homologous protein of USP5, is the only STAT3 DUB reported to date and has been studied in NSCLC 19, we wondered whether USP5 could directly interact with and deubiquitinate STAT3 to inhibit the ubiquitinated degradation of STAT3 and stabilize the STAT3 protein. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.