Here, we revealed that p62 interacted with STAT3 in vitro and in vivo, wheras α-hederin increased the expression of p62 protein, which plays an anti-inflammatory role 49, 50, and decreased p-STAT3 (Tyr705) expression in colon tissues of CRC-mice, as well as weakened the interaction between p62 and STAT3, and reduced the translocation of STAT3 from the cytoplasm to the nucleus. Here, STAT3 is linked to colorectal carcinoma.