We noticed that compared with the control group, p62 was expressed at lower levels, whereas Beclin was highly expressed in the colon tissues of CRC mice, which was consistent with a previous report 52, demonstrating that p38 MAPK/STAT3 signaling was activated, followed by the induction of autophagy in the progression of CRC, which led to a positive feedback loop that amplified inflammation. Here, SQSTM1 is linked to colorectal carcinoma.