Ubiquitin specific peptidase 5 (USP5) is an important member of the ubiquitin-specific protease (USP) family, that is the largest family of DUBs 22, which is involved in the ubiquitin pathway that promotes tumorigenesis by deubiquitinating and stabilizing tumor proteins 25 and is involved in inflammatory responses 26. Here, USP5 is linked to neoplasm.