CCN2 and cancer: YAP siRNA induced a decrease in the mRNA level of MybL1, whereas ablation of MyBL1 led downregulation of YAP (Fig. 5C). In addition, knockdown of either YAP or MybL1 decreased the expression of the YAP down-stream target genes Connective Tissue Growth Factor (CTGF) and Cysteine-Rich Angiogenic Inducer 61 (Cyr61) (Fig. 5C). Of note, both CTGF and Cyr61 are known to up-regulate cancer metastasis26, 27.