Specifically, deep infiltrating endometriosis (DIE) lesions exhibit significantly higher p16 expression compared to matched eutopic endometrium, along with elevated IL-1β levels, while further analyses reveal that peritoneal fluid and the peri-lesional microenvironment in these patients contain multiple proinflammatory cytokines—including IL-6, IL-8, and IL-1β—showing substantial overlap with the SASP secretory profile 48. The gene discussed is IL6; the disease is endometriosis.