GSDME and retinal degeneration: In this study, light-exposed Abca4-/-Rdh8-/-Gsdme-/- mice exhibited significantly improved retinal function and reduced retinal degeneration compared to light-exposed Abca4-/-Rdh8-/- mice, as evidenced by recovery of the ERG a-wave and b-wave amplitudes, increased retinal thickness and photoreceptor ONL thickness, and reduced fundus lesions and RPE tight junction disruption (Figure 1A-1F).