Consistent with cDNA array results, IHC analysis on a colon cancer tissue microarray revealed that the expression of ETV4 protein was upregulated in CRC tissues compared to normal tissues (p<0.001, Fig.1g and Supplementary Table S8) and the expression of ETV4 protein was significantly associated with lymphatic metastasis (p<0.01, Fig.1h and Supplementary Table S8) and pathologic grades (p<0.01, Fig.1i and Supplementary Table S8). The gene discussed is ETV4; the disease is malignant colon neoplasm.