LOXL2 and colorectal carcinoma: To further elucidate how ETV4/LOXL2 promote EMT and metastasis in CRC cells, we first identified 241 genes of which the Pearson correlation coefficient with LOXL2 was greater than 0.7 via TCGA database, and combined with 6814 up-regulated differential expression genes (|log2FC| ≥ 2.0) in our previous ETV4 overexpression RNA-seq data, finally yielding 79 candidate genes (Fig.6a and Supplementary file 3).