Interestingly, NID1 promoter was highly methylated in colorectal cancer, and the differentially expressed gene in ETV4 overexpression RNA-seq data was enriched in the gene set MCGARVEY_SILENCED_BY_METHYLATION_IN_COLON_CANCER (Fig.3b), which indicates that ETV4 might regulate NID1 expression by mediating the methylation level of NID1 promoter. This evidence concerns the gene ETV4 and colorectal cancer.