Furthermore, we also found that NID1 knockdown attenuated the level of p-ERK1/2 in CRC cell lines stably overexpressed ETV4 (Fig.7a) while NID1 overexpression resulted in a higher level of p-ERK1/2 in ETV4sh-CRC cell lines (Fig.7b). This evidence concerns the gene ETV4 and colorectal carcinoma.