To confirm the above bioinformatics results, the human CRC cDNA array from Origene was used to detect the ETV4 mRNA expression, and the results showed that ETV4 was indeed remarkably elevated in CRC samples compared with the normal colorectal tissues (p<0.001, Fig.1d), and of note, the expression level of ETV4 mRNA was positively correlated with lymphatic metastasis (p<0.001, Fig.1e) and pathologic grades (p<0.001, Fig.1f). The gene discussed is ETV4; the disease is colorectal carcinoma.