FOSL2 and pulmonary fibrosis: In conclusion, our findings reveal a pro-fibrotic role of the TF Fra2 in silica-exposed mice, which significantly attenuates silica exposure-induced lung fibrosis in silica-exposed mice after silencing of highly expressed Fra2 in silica-exposed mice using adeno-associated viruses and suggests that TGF-β1 may be a target of Fra2 transcriptional activation.