SERPINE2 and Cirrhosis: Among these, PN-1 inhibition induced earlier fibrinolysis in patients with cirrhosis than in healthy individuals, as shown by a shorter lysis onset time in the former than in the latter (Table 4), as well as by a 1.6 times greater reduction in lysis onset time induced by PN-1 inhibition in patients with cirrhosis than in healthy individuals (Fig. 3C).