SERPINE2 and Cirrhosis: Our observation that PN-1 plays a more predominant role in the regulation of fibrinolysis than of coagulation in patients with cirrhosis is unusual, as PN-1 better inhibits thrombin than tPA (Ka = 6–8.3 × 105 M-1 s-1 for thrombin vs. Ka = 1.2–3 × 104 M-1 s-1 for tPA).