Univariate analysis revealed that RDW (OR=1.947), APACHE II score (OR=2.303), PCT (OR=1.423), IL-6 (OR=1.237), CRP (OR=1.212), cystatin C (OR=1.324), and the main source of infection (OR=1.478) were significantly associated with the development of AKI in children with sepsis. The gene discussed is CRP; the disease is acute kidney injury.