This study aimed to develop a risk score model for predicting acute kidney injury (AKI) in children with sepsis, using red blood cell distribution width (RDW), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and additional biomarkers (PCT, IL-6, CRP, and cystatin C) based on logistic regression (LR) analysis. This evidence concerns the gene CRP and acute kidney injury.