Our patient was diagnosed by chance during the anemia workup with HHCS after laboratory testing revealed hyperferritinemia with concurrent iron overload (high ferritin), the causes of secondary iron overload (alcohol use disorder, nonalcoholic fatty liver disease, and hepatitis C virus) were ruled out, and a positive family history of HH (our genetic analysis revealed a heterozygous carrier status for the H63D variant of the HFE gene) and cataract was elicited. The gene discussed is HFE; the disease is Tangier disease.