In the case of SCD, adenine base editors (ABEs) are designed to convert the pathogenic adenine (A) within the Glu6Val mutation (GAG → GTG) in the HBB gene to a guanine (G), thereby creating a non-pathogenic variant, such as the Makassar variant (GCG), that does not induce sickling. This evidence concerns the gene HBB and Schnyder corneal dystrophy.