Furthermore, a study by Aaggini et al. [16] identified gain-of-function mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), a key component of the PI3K pathway, in 70% of conventional angiolipomas (9 of 13 cases) and in all cellular angiolipomas (5 cases). The gene discussed is PIK3CA; the disease is angiolipoma.