GPT and cholestasis: According to Hy’s law, the concurrence of marked hepatocellular injury (alanine aminotransferase or aspartate aminotransferase (ALT or AST) >3× the upper limit of normal (ULN)) and hyperbilirubinemia (bilirubin >2× ULN) in the absence of significant cholestasis (alkaline phosphatase (ALP) <2× ULN) is predictive of severe DILI [7].