For example, Sharma et al. reported anti-TPO positivity in approximately 58.3% of subjects in their study with subclinical hypothyroidism, which is significantly lower than the rate we found in both subclinical and overt hypothyroidism [4]. Similarly, other Indian data also indicate an increasing recognition of autoimmunity as the leading cause of hypothyroidism in iodine-sufficient regions [2]. This evidence concerns the gene TPO and Autoimmunity.