Furthermore, Yılmaz et al. reported significant upregulation in plasma levels of both total and acylated ghrelin among individuals diagnosed with chronic periodontitis among male subjects; however, no measurable correlation was observed between ghrelin levels and clinical periodontal parameters, indicating a complex and possibly multifactorial relationship between ghrelin and periodontal disease pathogenesis [31]. This evidence concerns the gene GHRL and chronic periodontitis.