CD8A and neoplasm: Among the 10 proteins, CXCL10 and TRIM36 stand out as key pro-immune mediators: CXCL10’s upregulation in BC plasma reflects enhanced recruitment of CD8+ T cells and NK cells to the TME, while TRIM36’s upregulation further amplifies anti-tumor immunity by ubiquitinating PD-L1-reducing its surface expression on tumor cells and relieving T cell exhaustion (25, 26).