CD274 and non-small cell lung carcinoma: In non-small-cell lung cancer, the NSUN2/ALYREF axis deposits m5C and promotes nuclear export/stability of PD-L1 mRNA, increasing PD-L1 abundance and facilitating T-cell evasion; perturbing NSUN2 or ALYREF reduces PD-L1 and restores antitumor immunity in mouse and human systems.