ALKBH5 and neoplasm: Two robust, orthogonal lines of evidence now show that m6A readers in the myeloid compartment (YTHDF1 in DCs; YTHDF2 in myeloid cells) act as brakes on the STING–IFN-I axis after irradiation, while tumor-intrinsic erasers (FTO; ALKBH5) and m5C writers (NSUN6) tune DNA repair and ferroptosis to set the radiation-response threshold.