METTL3 and colorectal cancer: Second, CAFs can export the writer itself: multiple studies show METTL3 packaged in CAF exosomes enters cancer cells to install m6A on metabolic transcripts—SLC7A5 (LAT1) in NSCLC and ACSL3 in colorectal cancer (CRC)—thereby stabilizing targets, reprogramming glutamine/FA metabolism, suppressing ferroptosis, and accelerating metastasis; knockdown of exosomal METTL3 curtails tumor growth in vivo.