FTO inhibition + radiotherapy enhanced tumor control without worsening normal-tissue toxicity; reader targeting (YTHDF1/2) + RT or RT+ICB amplified STING–IFN-I signaling and T-cell priming; METTL3 inhibition combined with venetoclax overcame acquired resistance in AML. The gene discussed is METTL3; the disease is acute myeloid leukemia.