However, in IL-4 levels, a significant decrease was only observed in healthy and gingivitis (p = 0.04 and p = 0.03, respectively), while in IL-12p70 the decrease was significant in all periodontal disease stages (p < 0.0001 for heathy, p = 0.002 for gingivitis, and p = 0.002 for periodontitis). This evidence concerns the gene IL4 and periodontal disorder.