IL4 and type 1 diabetes mellitus: Supporting this hypothesis, levels of IL-4 and IL-12p70 — both associated with adaptive immune responses — were also decreased in T1DM patients across all periodontal stages (F (1, 172) = 15.04, and p = 0.0001 for IL-4 and F (1, 179) = 57.06 and p < 0.0001 for IL-12p70, Figures 2I, J).