FLT3 and acute myeloid leukemia: FMS-like tyrosine kinase 3 (FLT3) is a transmembrane receptor tyrosine kinase highly expressed in acute myeloid leukemia (AML), particularly in cases harboring internal tandem duplication (FLT3-ITD) or tyrosine kinase domain (FLT3-TKD) mutations, which occur in approximately 30% of patients.