Several SNPs have been reported on the promoter region of IL-6 located at position −597G/C (rs1800797) (13), −572G/C (rs1800796) (13–16), and −174G/C (rs1800795) (13, 15, 17, 18) in the promoter region of IL-6 and have been associated with susceptibility to RA. This evidence concerns the gene IL6 and rheumatoid arthritis.