IL6 and rheumatoid arthritis: The patients with RA with high levels of IL-6 (≥27.3 pg/mL) showed a longer morning stiffness time (p = 0.003), a higher functional disability score (p = 0.009), greater clinical activity (p < 0.001), and an increased number of tender and swelling joints (all p < 0.001); furthermore, they had higher levels of ESR (p = 0.006), hsCRP (p < 0.001), and RF (p = 0.033) (Table 4).