Among these patients, immunological data at M3 showed that OI group exhibited significantly lower proportions and absolute counts of CD3+ T cells (p = 0.034 and p = 0.010, respectively), as well as reduced counts of both CD4+ and CD8+ T cells (p = 0.024 and p = 0.005, respectively) (Supplementary Table S6) while NK and B cell populations was similar in all groups. Here, CD8A is linked to osteogenesis imperfecta.